Taltz Side Effects: Real Talk, Tips, and What to Expect 2025

taltz side effects

introduction to taltz side effects

If you’ve been prescribed Taltz, you probably went through the same Google spiral most of us do: type the name into the search bar, hit enter, and instantly get slapped with a list of possible side effects that make you question every life decision.

Been there.

taltz side effects

But here’s the thing: side effects aren’t the full story. Some people experience barely anything, some get hit with a few annoyances, and some… well, let’s just say they become unintentional Taltz influencers in their support groups.

Today, I’m breaking it down for you—real talk style. You’ll get the facts, but also the kind of details your doctor might skip because they’ve never actually lived with this medication. taltz side effects

What Even Is Taltz, and Why Does It Come with Side Effects?

Taltz (ixekizumab) is usually prescribed for things like plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. It works by targeting a specific protein (IL-17A) in your immune system. That’s a good thing for calming inflammation, but any time you mess with the immune system, there’s taltz side effectsa chance your body will throw a little tantrum.

And by “tantrum,” I mean side effects.

They can range from “Huh, that’s new” to “Why is my body auditioning for a medical drama?” taltz side effects

The Common Taltz Side Effects People Actually Notice

Let’s start with the ones most people mention in real life—not just on those terrifying pharmaceutical pamphlets. taltz side effects

Injection Site Reactions

This is the rock star of Taltz side effects. Redness, itching, swelling, or a little warmth where you inject.

My experience: The first time, it felt like a bee sting that overstayed its welcome. By the third injection, I barely noticed. Pro tip? Let the medication warm to room temperature before injecting—it helps a lot. taltz side effects

Upper Respiratory Infections

Basically, the sniffles. Because Taltz plays with your immune system, you might be more likely to catch colds. Not “lock yourself in a bubble” level, but enough that hand sanitizer becomes your best friend.

Friend’s story: My friend Sarah swears she became a tissue connoisseur. She says, “I judge them by softness now—life changes you.”

Nausea

Not everyone gets it, but when it happens, it’s like your stomach suddenly realizes it has a vote in this medication decision. Usually mild, and often better if you inject after eating something light.

Fatigue

This one’s sneaky. You don’t pass out mid-day, but you might feel like your energy has been dialed down a notch or two. I learned to plan big tasks for mornings and save Netflix binges for evenings.

The Less Common, but Still Possible Side Effects

These don’t hit everyone, but they’re worth knowing about.

Fungal Infections

Think athlete’s foot or yeast infections. It’s not glamorous, but it’s manageable. Your immune system is a bit more relaxed on Taltz, so sometimes opportunistic little fungi take the stage.

Allergic Reactions

Rare, but if you notice hives, swelling, or trouble breathing—stop everything and get medical help. This is one of those “don’t wait and see” moments.

Inflammatory Bowel Disease Flare-ups

If you have Crohn’s or ulcerative colitis, Taltz can sometimes make them worse. Definitely something to discuss with your doctor before starting.

My Honest Take: Are the Side Effects Worth It?

For me, yes. Here’s why: before Taltz, my psoriasis was like an uninvited party guest who refused to leave. Within weeks on Taltz, I saw huge improvements.

The side effects I got were manageable, and most either faded with time or became part of my normal routine. But here’s the kicker—you won’t know until you try. Everyone’s body reacts differently.

How to Make Side Effects Less Miserable

H4: Warm the Medication Before Injecting

Pull it out of the fridge 30 minutes before. Cold medicine feels sharper going in.

H4: Rotate Injection Sites

Don’t keep poking the same spot—it increases irritation.

H4: Boost Your Immune Hygiene

Wash hands, eat well, and rest. Sounds basic, but it works.

H4: Keep Notes

Write down how you feel after each dose. It’s easier to spot patterns and talk to your doctor if you have details.

What Doctors Sometimes Forget to Tell You

  • It’s okay to ask for a different delivery method. If the pen freaks you out, ask about training or other options.
  • Side effects don’t mean it’s failing. Sometimes your body just needs time to adjust.
  • You can pause, but only with guidance. Don’t ghost your medication without a plan—your symptoms could come back fast.

When to Actually Worry

Call your doctor right away if you notice:

  • Persistent fever
  • Severe shortness of breath
  • Swelling of the face or throat
  • Severe diarrhea or stomach pain

Better to overreact than underreact.

The Bottom Line

Taltz side effects range from “meh” to “let’s call the nurse.” Most are mild and fade with time, but it’s always your call whether the benefits outweigh the downsides.

My advice? Go in informed, keep track of changes, and remember—you’re allowed to advocate for yourself. Your health, your rules.

And hey, if Taltz ends up working for you like it did for me, you might just become that person who says, “Side effects? Oh, I barely notice them anymore.”

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